Genotoxicity refers to the capacity off a substance to damage genetic material within cells through interactions with the DNA sequence and structure. Mutagenicity refers to the capacity of a substance to cause permanent, transmissible changes to genetic structure or amount of genetic material.
Aragen Biosafety Solutions offers a broad array of genotoxicity/mutagenicity studies, both in vivo and in vitro. Robust historical control data developed in our laboratories for various vehicles and positive controls convincingly supports the outcome of the experiments. We will provide you with reliable, efficient data as you screen libraries of multiple compounds for de-risking your portfolio and candidate selection. Further, we will also support you with GLP safety studies as you move towards regulatory filings.
The genotoxicity testing protocols at Aragen Biosafety Solutions are developed and validated by our experts in regulatory toxicology. The study reports have been accepted by regulatory agencies across the globe. While experimental designs for various test items will vary with their type, the intended application and the regulatory requirements, a consultation with our toxicology and regulatory experts will create the most appropriately tailored testing strategy for your product.
In Vitro
In Vivo
For in vivo and in vitro micronucleus tests, we are using state of art flow cytometer instead of manual slide counting
In Vitro Toxicology/In vitro Alternatives:
