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Solutions Small Molecules Discovery Integrated Drug Discovery New AIDD Biology In-vivo Animal Models

In-vivo Animal Models

In-vivo Pharmacology: Animal Models

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Oncology

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Inflammation/Pain

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Metabolic Disorders

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Fibrosis

  • Validated disease models
  • Customize existing models to meet specific client needs or develop novel, fit-for-purpose models

Oncology

  • Xenograft Models- breast, ovarian, colon, melanoma, multiple myeloma, lung etc.
  • Syngeneic Models: melanoma, breast, colon etc.
  • PK & MTD studies in tumor bearing mice

Fibrosis Models

  • Bleomycin induced Idiopathic Pulmonary Fibrosis (IPF) in mouse & rats
  • Carbon Tetrachloride (CCL4) induced liver fibrosis
  • Non – Alcoholic Steatohepatitis (NASH)
  • Unilateral ureteral obstruction (UUO)
  • 5/6 Nephrectomy in rats

Inflammation Models

  • Psoriasis (Imiquimod, IL23-induced)
  • Delayed type hypersensitivity (oxazolone model)
  • MOG-induced Experimental Autoimmune Encephalomyelitis (EAE)
  • Dextran sulphate sodium (DSS) induced colitis
  • Collagen-Induced Arthritis in in DBA/1J Mice Inflammatory cytokines from plasma and tissues

Pain Models

  • Neuropathic (CCI, Chung, STZ and paclitaxel)
  • Brennan model
  • Inflammatory (CFA, Carrageenan, Formalin & MIA induced mechanical  allodynia or thermal hyperalgesia)

Cardiovascular & Metabolic Diseases

  • Diet induced obesity (food intake, body weight and clinical chemistry)
  • Acute (corn oil or intralipid induced lipid intolerance
  • Glucose tolerance test (OGTT, ipGTT, ivGTT)
  • Chronic Kidney disease: UUO & 5/6 Nephrectomy
  • Monocrotaline-induced Pulmonary Arterial Hypertension (PAH)
  • Bleeding Model in rats

Pk-Pd & Non Glp Toxicity Studies

  • Oral, IV, IP, SC administration
  • MTD and repeat dose toxicity studies in rodents

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