Integrated Drug

Leveraging the benefits of connected solutions.

An integrated partnership approach to early phase discovery is vital to the swift and efficient progress of your molecule. Our dedicated multidisciplinary team – comprising talented medicinal, synthetic and computational chemists, biologists, pharmacologists, process development and formulation scientists – offers a unified strategy to advance customer programs through critical decision milestones. Speed, scientific rigor, flexibility and data integrity are key Aragen differentiators.

Every integrated discovery program is assigned a project lead from chemistry and biology respectively, closely monitored by their department heads. The size and composition of our scientific teams are customized based on program needs/stage and timelines. To address specific program challenges, expertise in chemistry and biology can be accessed from our larger talent pool, on need basis.

XLRATE™, our proprietary project management platform, enables our customers and scientists to focus on science, while dedicated project management, logistics and supply chain teams ensure program efficiency, timely communication, and rapid turnaround time.

25+ Integrated Programs

with large, mid-sized, small and virtual pharma, and biotechs

10+ INDs Enabled

from integrated discovery programs

Expertise in Key
Therapeutic Areas

Oncology, Pain, Inflammation, Fibrosis, Cardiovascular and Metabolic Diseases


proprietary project management platform

1,600+ Strong Scientific

located in India and USA

Target Validation and Hit Generation

Hit identification

Hit to



  • HTS Analysis
  • virtual screening
  • IP Analysis
  • Tool Compounds
  • Hit validation
  • Focused library design and synthesis
  • Chemical series categorization/ prioritization
  • Robustness check of in silico models
  • SAR analysis
  • SPR profiling
  • Back-up strategy
  • Rapid scale-up
  • Preformulation
  • Route scouting and development
  • Process safety assessment
  • Kilo scale-up
  • Scalability studies
  • Pathway analysis
  • Primary assay
  • HTS
  • Reagent generation
  • In vitro assays:
    – Primary and functional assays
    – Rodent selectivity
  • ADME assays:- Solubility and permeability
    – Stability
    – CYP inhibition
  • In vitro assays
  • Target selectivity
  • Mechanistic assay
  • ADME assay
  • PP binding
  • Rodent PK
  • In vivo target engagement
  • In vivo efficacy
  • PK/PD
  • In vitro safety
  • Rodent tox
  • Canine PK
  • Canine tox
  • CYP inhibition
  • Reactive metabolites, tissue distribution
  • GLP tox
  • Human dose prediction
XLRATE – Project Management Platform