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Publications

2019

Chemistry

Galeterone and the Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-resistant Prostate Cancer Preclinical Models in vitro and in vivo

Andrew K. Kwegyir-Afful, Senthilmurugan Ramalingam, Vidya P. Ramamurthy, Puranik Purushottamachar, Francis N. Murigi, Tadas S. Vasaitis, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Sudhir Tiwari, Pratima Srivastava, Ivo P. Nnane, Arif Hussain, Yun Qiu, David J. Weber, Vincent C. O. Njar
(Basel). 2019 Nov; 11(11), 1637

Chemistry

Oxidative Degradation Profile Studies of Tavaborole by a Validated Stability Indicating RP-UPLC method: Isolation and Characterization of Novel Degradant using 2D-NMR and HRMS

Umamaheshwar Puppala , Vishnu Murthy Marisetti, Koduri S V Srinivas, K Venkateshwara Reddy, Muralidharan Kaliyaperumal, Raju Doddipalla
Biomedical Chromatography | Language: English, Database: CAplus and MEDLINE

Chemistry

Biology

Mass Spectrometry as a Workhorse for Preclinical Drug Discovery: Special Emphasis on Drug Metabolism and Pharmacokinetics

Vijayabhaskar Veeravalli, Lakshmi Mohan Vamsi Madgula, Pratima Srivastava
10.5772/intechopen.88385. In book: Mass Spectrometry – Future Perceptions and Applications

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Biology

Investigation of the Inhibition of Eight Major Human Cytochrome P450 Isozymes by a Probe Substrate Cocktail In Vitro with Emphasis on CYP2E1

Guru R. Valicherla, Amrut Mishra, Srinivas Lenkalapelly, Bhupathi Jillela, Femi M Francis, Lakshman Rajagopalan, Pratima Srivastava
Xenobiotica 1-21. 10.1080/00498254.2019.1581301

Biology

Oral Pharmacokinetics of Sildenafil in the Presence of CYP3A4-Inducer and -Inhibitor using Cannulated and Non-Cannulated Male Swiss Albino Mice

Satish Kumar, Rajkumar Jadi, Bhagheeradha Lakkimsetti, Surendra Yadav Ravulapalli, Sudhir Kumar Tiwari, Pratima Srivastava, Ritu Paliwal, Lakshman E Rajagopalan
Indian Journal of Applied Research 9: 30-34

Biology

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation In Drug Discovery and Development

Abdul Naveed Shaik, Ansar Ali Khan
ADMET & DMPK 7(1) (2019) 1-3; DOI: 10.5599/admet.667

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Biology

2018

Chemistry

Design, Synthesis and Anticancer Evaluation of Spiro[Cyclohexane-1,1’-Indene]-2,5-Diene Analogues

Sivarami Reddy Gangireddy Venkata, Dr Umesh C. Narkhede, Dr Vinod D Jadhav, Dr Naidu Gangu, Yamini Bobde, Dr Balaram Ghosh
ChemistrySelect 2018, 3, 12139– 12143

Chemistry

An Efficient Method for the Preparation of N -Formamides using Propylphosphonic Anhydride (T3P)

Kandula V, Gudipati R, Chatterjee A, Yennam S, Behera M
Venu Kandula, Ramakrishna Gudipati, Anindita Chatterjee, Satyanarayana Yennam, Manoranjan Behera
SynOpen (2018), 2(2), 0176-0179 | Language: English, Database: CAplus

Chemistry

An Efficient Microwave-Assisted Propylphosphonic Anhydride (T3P®)-Mediated One-Pot Chromone Synthesis via Enaminones

C Balakrishna, V Kandula, R Gudipati, S Yennam, Uma Devi P, M Behera
Synlett, 2018, 29, 1087-1091

Chemistry

An Efficient One-Pot Green Approach for the Synthesis of A-aminonitriles with Alsba-15 as Nano Tubular Catalytic Reactor

M. Krishna Kolli, S Reddy Dadireddy, P Elamathi, G Chandrasekar, S Chidara
Iranian Journal of Energy and Environment 8 (4): 305-317, 2017

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Chemistry

The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group

Magdalena R Andrzejewska, Prasanna K Vuram, Narender Pottabathini, Venkateshwarlu Gurram , Siva Subrahmanyam Relangi, Kirill A Korvinson, Raju Doddipalla, Lothar Stahl, Michelle C Neary, Padmanava Pradhan, Somesh Sharma, Mahesh K Lakshman
Advanced Synthesis & Catalysis, 2018, 360, 1–9

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Chemistry

Highly Efficient Metal-Free One-Pot Synthesis of α- aminophosphonates through Reduction followed by Kabachnik–Fields Reaction Using Three-Component System

Murali Krishna Kolli, Palani Elamathi, Govindasamy Chandrasekar, Vishweshwar Rao Katta, Gajendrasinh Balvantsinh Raolji
Synthetic Communications® 2018, VOL. 48, NO. 6, 638–649

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Chemistry

First Total Synthesis of Medicinally Important 3,4,7-Trimethoxy-9, 10-Dihydrophenanthrene-1,5-Diol

Sivarami Reddy Gangireddy Venkata, Umesh C Narkhede, Vinod D Jadhav, Ch Gangu Naidu
Tetrahedron Letters 59 (2018) 1670–1673

Chemistry

Biology

Preclinical Pharmacokinetics, Antitumor Activity and Single Ascending Dose Tolerability of GBO-006 Nanosuspension, A Selective Polo-Like Kinase 2 (PLK2) Inhibitor

Srinivas Maddi, Srinivas Lenkalepally, Pratima Srivastava, Jeyaraj Duraiswamy, Arnab Roy Chowdhury, Lakshman Rajagopalan, Jang B Gupta
Drug Invention Today 10: 1-9

Biology

2017

Chemistry

"One-Pot" Selective Synthesis of 3,4-Disubstituted Pyrroles and Benzo[F]Indole-4,9-Diones from 1,3-Indanedione, Aromatic Aldehydes and Tosmic

Anjaiah Aitha, Nagaraju Payili, Santhosh Reddy Rekula, Satyanarayana Yennam, Jaya Shree Anireddy
ChemistrySelect, Volume 2, Page-7246-7250, 2017

Chemistry

Synthesis of Novel Fused Chromone–Pyrimidine Hybrids and 2,4,5-Trisubstituted Pyrimidine Derivatives via ANRORC Rearrangement

M Sambaiah, K Raghavulu, K Shiva Kumar, Satyanarayana Yennam, Manoranjan Behera
New Journal of Chemistry, 2017, 41, 10020-10026

Chemistry

A Novel Synthesis of Chromone Based Unnatural α-Amino Acid Derivatives

Venu Kandula, Ramakrishna Gudipati, Anindita Chatterjee, Muralidaran Kaliyaperumala, Satyanarayana Yennam, Manoranjan Behera
Journal of Chemical Sciences (Berlin, Germany) (2017), 129(8), 1233-1245.

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Chemistry

One-Pot Synthesis of 7-chloro-2-arylthieno[3,2-b]pyridin-3-ols and their Derivatization to the Corresponding Arylamino, Arylthio, and Aryloxy

Srinu Puvvala, Vinod D Jadhav, Umesh C Narkhede, Sheikh M Farooq, and Ch.Venkataramana Reddy
Journal of Heterocyclic Chemistry, 54, 3030 (2017).

Chemistry

Pd-PEPPSI-Ipentcl: A New Highly Efficient Ligand-Free and Recyclable Catalyst System for the Synthesis Of 2-Substituted Indoles via Domino Copper-Free Sonogashira Coupling/Cyclization

Murali Krishna Kolli, Nagul Meera Shaik, Govindasamy Chandrasekar, Sridhar Chidara, Raghu Babu Korupolu
New Journal of Chemistry, 2017, 41, 8187–8195

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Chemistry

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

Srinu Puvvala, Vinod D Jadhav, Umesh C Narkhede, MVVSRN Anji Karun, Ch. Venkata Ramana Reddy
Synthesis 2017; 49(12): 2768-2774

Chemistry

Synthesis of Spiroindene-1,3-Dione Isothiazolines via a Cascade Michael/1,3-Dipolar Cycloaddition Reaction of 1,3,4-Oxathiazol-2-one and 2-Arylidene-1,3-Indandiones

Anjaiah Aitha, Satyanarayana Yennam, Manoranjan Behera, Jaya Shree Anireddy
Tetrahedron Letters 58 (2017) 578–581

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Chemistry

Biology

Cytochrome P450 Enzymes, Drug Transporters and their Role in Pharmacokinetic Drug-Drug Interactions of Xenobiotics: A Comprehensive Review

Srinivas Maddi, Thirumaleswara Goud, Pratima Srivastava
Peertechz Journal of Medicinal Chemistry and Research 3(1): 001-011.

Biology

Characterization of 1-Aminobenzotriazole and Ketoconazole as Novel Inhibitors of Monoamine Oxidase (MAO): An In Vitro Investigation

Abdul Naveed Shaik, Barbara W LeDuc, Ansar A Khan
Eur J Drug Metab Pharmacokinet DOI 10.1007/s13318-017-0401-6

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Biology

2016

Biology

Drug Metabolism – Metabolite Identification Using Advance LC-MS/MS System

Vijayabhaskar V, Pratima Srivastava, Anoop Kumar, Manoj Pillai
Express Pharma May 2016

Biology

Chemistry

Design, Synthesis and Biological Evaluation of Diaziridinyl Quinone Isoxazole Hybrids

K Jones M Swapnaja, Satyanarayana Yennam, Murthy Chavali, Y. Poornachandra, C Ganesh Kumar, Krubakaran Muthusamy, Venkatesh Babu Jayaraman, Premkumar Arumugam, Sridhar Balasubramanian, Kiran Kumar Sriram
European Journal of Medicinal Chemistry, Volume 117, 2016, Pages 85–98

Chemistry

Design and Synthesis of Diaziridinyl Quinone Thiadiazole Hybrids via Nitrile Sulfide Cycloaddition Reaction as a Key Step

Anjaiah Aitha, Satyanarayana Yennam, Manoranjan Behera, Jaya Shree Anireddy
Tetrahedron Letters, Volume 57, 2016, 1507–1510

Chemistry

An Efficient Method for the Preparation of N-Formyl-Imide via Amidine using Propylphosphonic Anhydride (T3P®)

M Sambaiah, Ramakrishna Gudipati, K Shiva Kumar, Satyanarayana Yennam, Manoranjan Behera
Tetrahedron Letters, Volume 57, 2016, 403–406

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Chemistry

I2–DMSO Promoted Metal Free Oxidative Cyclization for the Synthesis of Substituted Indoles and Pyrroles

Addada Ramakrishnam Raju, Regalla Venkata Reddy, Vajja Mallikarjuna Rao, Vema Venkata Naresh, Anna Venkateswara Rao
Tetrahedron Letters 57 (2016) 2838–2841

Chemistry

A New Metabolite of Paricalcitol: Stereoselective Synthesis of (22Z)-Isomer of 1a, 25-Dihydroxy-19-Norvitamin D2

Ramakrishna Samala, Somesh Sharma, Manas K. Basu, K. Mukkanti, Frank Porstmann
Tetrahedron Letters, doi:10.1016/j.tetlet.2016.01.110

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Chemistry

An Efficient Synthesis of 8-Substituted Odoratine Derivatives by the Suzuki Coupling Reaction

Manoranjan Behera, P Ravi Kumar, C Balakrishna, B Murali, Ramakrishna Gudipati, Prasanta K Hota, Avinash B Chaudhary, A Jaya Shree, Satyanarayana Yennam
Journal of Chemical Sciences, doi: 10.1007/s12039-016-1042-z

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Chemistry

Biology

Preclinical Formulation for the Pharmacokinetics and Efficacy of GBO-006, a Selective Polo Like Kinase 2 (PLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer

Srinivas Maddi, Ravi Akkireddy, Srinivas Lenkalapelly, Pratima Srivastava, Joshodeep Boruwa, Chandra Deb, Arnab Roy Chowdhury, Duraiswamy A Jeyaraj, Ramana Reddy, Premkumar Reddy, Manoj Maniar, Sachin Bansal, Jang B Gupta
ADMET & DMPK 4: 314-326 doi.org/10.5599/admet.4.4.341

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Biology

Design, Synthesis, and Evaluation of (2S, 4R)-Ketoconazole Sulfonamide Analogs as Potential Treatments for Metabolic Syndrome

Benjamin E Blass, Pravin Iyer, Magid Abou-Gharbia, Wayne E Childers, John C Gordon, Mercy Ramanjulu, George Morton, Premkumar Arumugam, Joshodeep Boruwa, John Ellingboe, Sayan Mitra, Rajashekar Reddy Nimmareddy, Shalini Paliwal, Jamallamudi Rajasekhar, Savithiri Shivakumar, Pratima Srivastava 2, Raghuram S Tangirala, Konda Venkataramanaiah, Mahesh Yanamandra
Bioorg Med Chem Lett. 26:5825-5829. doi: 10.1016/j.bmcl.2016.10.016.

Biology

Synthesis of 6-Oxopyrimidin-1(6H)-Yl Benzamide Derivatives and Evaluation of their Antibacterial and Cytotoxic Activity

Kiran Devarasettya, Giri Tharikoppula, Tailor Sridhar, Laxminarayana Eppakayala, Mahesh Kyasani, Premkumar Arumugam, Srinivas Pusuluri
Synthetic Communications, Volume 46, Issue 3, 2016

Biology

Design, Synthesis and Biological Evaluation of Diaziridinyl Quinone Isoxazole Hybrids

K Jones M Swapnaja, Satyanarayana Yennam, Murthy Chavali, Y Poornachandra, C Ganesh Kumar, Krubakaran Muthusamy, Venkatesh Babu Jayaraman, Premkumar Arumugam, Sridhar Balasubramanian, Kiran Kumar Sriram
European Journal of Medicinal Chemistry, (Accepted, Mar 2016)

Biology

2015

Chemistry

Synthesis of New Kojic Acid Based Unnatural α-Amino Acid Derivatives.

C Balakrishna, Nagaraju Payili, Satyanarayana Yennam, P Uma Devi, Manoranjan Behera
Bioorg Med Chem Lett. 2015 Nov 1;25(21):4753-6. doi: 10.1016/j.bmcl.2015.07.099

Chemistry

Pd Catalyzed C–N Bond Forming Reactions of 6-Bromo-2-Cyclopropyl-3-(Pyridyl-3-ylmethyl)-4-quinazolin-(3H)-one at Room Temperature

Narender Pottabathini, Ramesh Garlapati, Venkateshwarlu Gurram, Suresh Poudapally, Pavan Kumar Machiraju, Somesh Sharma
Current Organocatalysis, 2213-3372

Chemistry

Facile and Short Synthesis of (+) 1-Hydroxy Indolizidine and (+) Coniceine from Picolinic Acid Ethyl Ester via Cross Claisen Condensation

S. Veeraswamy, R Venkat Ragavan, Y Narasimha Reddy, Satyanarayana Yennam, A Jayashree
Asian Journal of Chemistry; 27(5) 1667-1670, 2015

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Chemistry

Synthesis, In Vitro Anticancer And Antimycobacterial Evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino Derivatives

Naveen Polkam, Parsharamulu Rayam, Jaya Shree Anireddy, Satyanarayana Yennam, Hasitha Shilpa Anantaraju, Sriram Dharmarajan, Yogeeswari Perumal, Sudha Sravanti Kotapalli, Ramesh Ummanni, Sridhar Balasubramanian
Bioorganic & Medicinal Chemistry Letters; 25 (2015) 1398–1402

Chemistry

Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N–OH Deoxygenation, and Pd-Catalyzed C–C and C–N Bond Formation

Venkateshwarlu Gurram, Hari K Akula, Ramesh Garlapati, Narender Pottabathini, Mahesh K Lakshman
Advanced Synthesis & Catalysis 2015, 357, 451-462

Chemistry

Design, Synthesis, And Biological Evaluation Of Quinazoline Derivatives As α-glucosidase Inhibitors

Venkateshwarlu Gurram, Ramesh Garlapati, Chiranjeevi Thulluri, Nagaraju Madala, Kumara Swamy Kasani, Pavan Kumar Machiraju, Raju Doddapalla, Uma Addepally, Rambabu Gundla, Balaram Patro, Narender Pottabathini
Medicinal Chemistry Research, 2015, 24, 2227-2237

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Chemistry

Biology

Breaking the Sensitivity Limitations of Cytochrome P450 Oxidation Product: Dansyl Chloride Derivatization Of 4-OH Mephenytoin, a CYP2C19 Metabolite and its Application to In Vitro CYP Inhibition Assay

V Vijaya Bhaskar, Pratima Srivastava, Sriram Rajagopal
Journal of Chromatography B, 989:27-36 Impact factor: 2.99; doi:10.1016/j.jchromb.2015.02.031

Biology

Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Estimation of Solutol HS15 and its Applications

V Vijaya Bhaskar, Anil Middha, Pratima Srivastava, Sriram Rajagopal
Journal of Pharmaceutical Analysis 5:120-129; doi 10.1016/j.jpha.2014.09.002

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Biology

Development and Application of PI3K Assays for Novel Drug Discovery

Mahesh Yanamandra, Sayan Mitra, Archana Giri
Expert Opinion on Drug Discovery 10, no. 2 (2015): 171-186

Biology

2014

Chemistry

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

Kendra K. Harris, Allison Fay, Han-Guang Yan, Pratima Kunwar, Nicholas D. Socci , Narender Pottabathini, Ramakrishna R. Juventhala, Hakim Djaballah, Michael S. Glickman
ACS Chemical Biology, Article ASAP, DOI: 10.1021/cb500573z, Publication Date: September 15, 2014

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Chemistry

Biology

Design, Synthesis and Biological Evaluation of Novel Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors

Torsten Dunkern, Sunil Chavan, Digambar Bankar, Anuja Patil, Pritee Kulkarni, Prashant S Kharkar, Arati Prabhu, Heike Goebel, Edith Rolser, Waltraud Burckhard-Boer, Premkumar Arumugam, Mahindra T Makhija
Journal of Enzyme Inhibition and Medicinal Chemistry, 29(3):408-19, Jun. 2014

Biology

Chemistry

Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

P Ravi Kumar, Manoranjan Behera, M Sambaiah, Venu Kandula, Nagaraju Payili, A Jaya Shree and Satyanarayana Yennam
Journal of Amino Acids, Volume 2014 (2014), Article ID 721291

Chemistry

First Total synthesis of (-)-Auranomide C and its Derivatives

Kumaraswamy Sorra, Khagga Mukkanti, Srinivas Pusuluri
Synthesis 2014, 46, 189-194

Chemistry

Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines

Kumaraswamy Sorra, Chien-Shu Chen, Chi-Fen Chang, Srinivas Pusuluri, Khagga Mukkanti, Chi-Rei Wu, Ta-Hsien Chuang
International Journal of Molecular Sciences 2014, 15, 16500-16510

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Chemistry

A Convenient and Efficient Synthesis of 2-(Het)arylthieno[3,2-b]pyridine-7(4H)-ones and 2,3-Di(het)arylthieno[3,2-b]pyridine-7(4H)-ones

Srinu Puvvala, Vinod D Jadhav, Sheikh M Farooq, C Venkata Ramana Reddy, Pavan Kumar Machiraju
Synthesis (Stuttgart), 2014; 46(24): 3319-3330

Chemistry

Pyrrolidine and Piperidine Based Chiral Spiro and Fused Scaffolds via Build/Couple/Pair Approach

Rajinikanth Mamidala, V Surendra Babu Damerla, Rambabu Gundla, M Thirumala Chary, YLN Murthy, Subhabrata Sen
RSC Advances, 2014, 4, 10619

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Chemistry

Biology

Effect of Milnacipran and Atorvastatin Alone and in Combination in Rodent Model of Inflammatory Pain

S Bansal, Savithiri Shivakumar, M Ande, Pratima Srivastava
American Journal of PharmTech Research 4: 970-979, ISSN: 2249-3387

Biology

Optimization of Bupivacaine Induced Subarachnoid Block by Clonidine: Effect of Different Doses of Oral Clonidine

Mamta Harjai, Jaishri Bogra, Rajni Gupta, R Gurumoorthi, Girish Chandra, Prithvi Kr Singh, Pratima Srivastava
Journal of Anesthesia Clinical Research 5:2-9

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Biology

A Randomized Double-Blinded Dose Response Study of the Fentanyl with Hyperbaric Ropivacaine in Caesarean Section

A Gupta, Jaishri Bogra, Prithvi K Singh, J K Kushwaha, Pratima Srivastava
Journal of Anesthesia Clinical Research 5:467-477. doi: 10.4172/2155-6148.1000467

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Biology

Atorvastatin Potentiates the Anti-Nociceptive Effect of Milnacipran in Carrageenan-Induced Inflammatory Pain Model in Rats

Sachin Bansal, Savithiri Shivakumar, M Ande, Pratima Srivastava
International Journal of Pharmacy & Therapeutics, 5(3), 2014, 213-219

Biology

Development of Phosphocellulose Paper-Based Screening of Inhibitors of Lipid Kinases: Case Study with PI3K𝝱

Mahesh Yanamandra, Labanyamoy Kole, Archana Giri, Sayan Mitra
Analytical Biochemistry, Volume 449, 15 March 2014, Pages 132–138

Biology

ATP Competition of PI3K Inhibitors using Phosphocellulose Paper Approach

Mahesh Yanamandra, Labanyamoy Kole, Archana Giri and Sayan Mitra
International Journal of Bioassays, Volume 3, No 09 (2014) pages 3276-3279

Biology

Liquid Chromatography/Tandem Mass Spectrometry Method for Estimation of Cholic Acid in Rat Plasma, Urine and its Application

Surendra Yadav R, Kilari Eswar Kumar
Journal of Analytical & Bioanalytical Techniques 2014, 5:4

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Biology

2013

Biology

Identification and Reduction of Matrix Effects caused by Cremophor EL In Bioanalysis using Liquid Chromatography/Tandem Mass Spectrometry

Vijaya Bhaskar V, Anil Middha, Sudhir Tiwari and Savithiri Shivakumar
Journal of Analytical & Bioanalytical Techniques, Vol 4, Suppl 167, June 2013

Biology

Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Estimation of Polyethyleneglycol 400 and its Applications

Vijaya Bhaskar V, Anil Middha, Sudhir Tiwari and Savithiri Shivakumar
Journal of Chromatography B, Vol 926, May 2013

Biology

Chemistry

Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis

Ramu Surakanti, Sumalatha Sanivarapu, Chiranjeevi Thulluri, Pravin S Iyer, Raghuram S Tangirala, Rambabu Gundla, Uma Addepally, YLN Murthy, Lakshmi Velide, Subhabrata Sen
Chemistry An Asian Journal, 2013, 8, 1168 – 1176

Chemistry

Facile Total Synthesis Of Gymnoconjugatin A and B

Ramakrishna Samala, Balaram Patro, Manas K Basu, NS Kameswara Rao and K. Mukkanti
Tetrahedron Letters, 2013, 54 (28), 3624–3626

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Chemistry

A Reagent Based DOS Strategy via Evans Chiral Auxiliary: Highly Stereoselective Michael Reaction Towards Optically Active Quinolizidinones, Piperidinones And Pyrrolidinones

Subhabrata Sen, Siva R Kamma, Rambabu Gundla, Uma Adepally, Santosh Kuncha, Sridhar Thirnathia and U Viplava Prasad
RSC Advances 2013, 3, 2404

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Chemistry

Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation

Subhabrata Sen, Rajanikanth Mamidala, Rambabu Gundla, MT Charya
Asian Journal of Organic Chemistry 2013, 2, 862 – 868

Chemistry

A Novel One-Pot Synthesis of 7-methoxy-2-arylthieno – [3,2-b] pyridine-3-ols in Domino Fashion

Srinu Puvvala, Vinod D Jadhav, Sheikh M Farooq, Balaram Patro, Ch. Venkata Ramana Reddy
Tetrahedron Letters 54 (2013) 5043–5047

Chemistry

Concise Total Synthesis of (-)-Erinapyrone B from D-(+)-Malic Acid

Ramakrishna Samala, Venkateshwarlu Gurram, Balaram Patroa, Narender Pottabathini, K Mukkanti
Synthetic Communications, 2013; 44:4, 500-506, DOI: 10.1080/00397911.2013.817017

Chemistry

Development of α-Glucosidase Inhibitors by Room Temperature C–C Cross Couplings of Quinazolinones

Ramesh Garlapati, Narender Pottabathini, Venkateshwarlu Gurram, Kumara Swamy Kasani, Rambabu Gundla, Chiranjeevi Thulluri, Pavan Kumar Machiraju, Avinash B. Chaudhary, Uma Addepally, Raveendra Dayam, Venkata Rao Chunduri and Balaram Patro
Organic & Biomolecular Chemistry, 2013, 11, 4778-4791

Chemistry

Ethyl-1-Imidazole Carbamate (EImC) as a Carbonylating Agent: Efficient Synthesis of Oxazolidin-2-ones from Amino Alcohols

S Veeraswamy, Indrasena Kummetha, R Ragavan, Satyanarayana Yennam, Jayashree Anireddy
Chemistry Letters, 42, 2013, No-2, P109-111

Chemistry

Biology

Identification and Reduction of Matrix Effects caused by Solutol HS15 in Bioanalysis using Liquid Chromatography/Tandem Mass Spectrometry

Vijaya Bhaskar V, Anil Middha, Sudhir Tiwari and Savithiri Shivakumar
Journal of Analytical & Bioanalytical Techniques. 04. 10.4172/2155-9872.1000166.

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Biology

Liquid Chromatography/Tandem Mass Spectrophotometry Method for Quantitation of Cremophor EL and its Applications

Vijaya Bhaskar V, Anil Middha
International Journal of Analytical Chemistry, Vol 2013, Suppl 2013, April 2013

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Biology

Bioanalytical Method Development and Validation for Estimation of Duloxetine Hydrochloride in Human Plasma using LC-MS/MS

K Bhanupriya, Savithri Shivakumar, A Ravi, KV Ramanjaneyulu, P Venkateswara Rao, AMS Sudhakar Babu Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry, Vol 1, Issue 1, 2013

Biology

Determination of Cremophor EL in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study

Vijaya Bhaskar V, Anil Middha, Sudhir Tiwari and Savithiri Shivakumar
Journal of Analytical & Bioanalytical Techniques, Vol 4, Suppl 163, March 2013

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Biology

Identification and Reduction of Matrix Effects caused by Polyethyleneglycol 400 in Bioanalysis using Liquid Chromatography/Tandem Mass Spectrometry

Vijaya Bhaskar V
International Journal of Pharmaceutical Innovation, Vol 3, Suppl 1, Jan-Feb 2013

Biology

2012

Biology

Virtual and Experimental High-Throughput Screening (HTS) in Search of Novel Inosine 5′-Monophosphate Dehydrogenase II (IMPDH II) Inhibitors

Torsten Dunkern, Arati Prabhu, Prashant S Kharkar, Heike Goebel, Edith Rolser, Waltraud Burckhard-Boer, Premkumar Arumugam & Mahindra T Makhija
Journal of Computer-Aided Molecular Design, 26(11):1277-92, Nov. 2012

Biology

Chemistry

An Efficient One-Step Chemoselective Reduction of Alkyl Ketones over Aryl Ketones in ß-diketones using LiHMDS and Lithium Aluminium Hydride.

S. Veera Swamy, K Indrasena Reddy, R Venkat Ragavan, K Tirumal Reddy, Satyanarayana Yennam, A Jayashree
Tetrahedron Letters, 53, 2012, 4651-4653.

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Chemistry

An Efficient Method for the Preparation of Mono A-aryl Derivatives of Diethyl Cyanoacetate using Ethyl-1-Imidazole Carbamate (ElmC)

Manoranjan Behera, R Venkatragavan, M. Sambaiah, Balaiah Erugu, J Rama Krishna Reddy, K Mukkanti, Satyanarayana Yennam
Tetrahedron Letters, 53, (2012), 1060-1062.

Chemistry

Pd-Catalyzed Amination of 6-halo-2-cyclopropyl-3-(pyridyl-3-ylmethyl) quinazolin-4(3H)-one

Ramesh Garlapati, Narender Pottabathini, Venkateshwarlu Gurram, Avinash B. Chaudhary, Venkata Rao Chunduri, Balaram Patro
Tetrahedron Letters, 2012, 53, 5162–5166.

Chemistry

Synthesis of Novel Isoxazole-benzoquinone Hybrids via 1,3-dipolar Cycloaddition Reaction as Key Step

P Ravi Kumar, ManoranjanBehera, K Raghavulu, AJaya Shree, Satyanarayana Yennam
Tetrahedron Letters 2012, 53, 4108–4113

Chemistry

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

Kumaraswamy Sorra, Chi-Fen Chang, Srinivas Pusuluri, Khagga Mukkanti, Min-Chiau Laiu, Bo-Ying Bao, Chia-Hao Su and Ta-Hsien Chuang
Molecules 2012, 17, 8762-8772

Chemistry

C–C Cross-Coupling Reactions of O6-Alkyl-2-Haloinosine Derivatives and a One-Pot Cross-Coupling/O6-Deprotection Procedure

Venkateshwarlu Gurram, Narender Pottabathini, Ramesh Garlapati, Avinash B Chaudhary, Balaram Patro, Mahesh K Lakshman
Chemistry-An Asian Journal, 2012, 7(8), 1853-1861

Chemistry

Enantiospecific First Total Synthesis of 7a(S)-p-hydroxyphenopyrrozin

Yugandhar Kothapalli, Ravi Kumar Puthukanoori, Srinivasa Rao Alapati
Tetrahedron Letters, 2012; 53, 1891–1893

Chemistry

Palladium Catalyzed Synthesis of Quinazolino [1,4] Benzodiazepine Alkaloids and Analogues

Kumaraswamy Sorra, Srinivas Pusuluri, K Mukkanti
Tetrahedron 2012; 68, 2001-2006

Chemistry

2011

Chemistry

Synthesis and Antibacterial Activity of 6-Substituted Anacardic Acid Derivatives

Subhakara Reddy Nallamilli, Ravi Kumar V, Himabindu V, B Ram, Srinivas Rao Aalapati
Letters in Drug Design & Discovery, 2011, 8, 972-979

Chemistry

Facile Two-Step Synthesis of Crispine A and Harmicine by Cyclopropylimine Rearrangement

Sanjay Saha, Ch. Venkata Ramana Reddy, Balaram Patro
Tetrahedron Letters, 2011, 52, 4014-16

Chemistry

Diversity-Oriented Synthesis of Amino Acids using Chiral Enolates

Subhabrata Sen, Siva R Kamma, Venkata R Potti, YLN Murthy, Avinash B Chaudhary
Tetrahedron Letters, 2011, 52, 5585-5588

Chemistry

Enantioselective Synthesis of Spirooxoindoles via Chiral Auxiliary (Bicyclic Lactam) Controlled SNAr Reactions

Subhabrata Sen, Venkata R Potti, Ramu Surakanti, YLN Murthy, Raghavaiah Pallepogu
Organic & Biomolecular Chemistry, 2011, 9, 626-632

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Chemistry

Synthesis and Antibacterial Activity of Anacardic Acid Derivatives

Subhakara Reddy Nallamilli, Ravi Kumar V, Himabindu V, B Ram, Srinivas Rao Alapati
Letters in Drug Design & Discovery, 2011, 8(7), 626-632

Chemistry

SPF32629A and SPF32629B: Enantioselective Synthesis, Determination of Absolute Configuration, Cytotoxicity and Antibacterial Evaluation

Srinivasa Rao Vegi, Shanthaveerappa K Boovanahalli, Balaram Patro, K Mukkanti
European Journal of Medicinal Chemistry, 2011, 46, 1803-1812

Chemistry

An Efficient Method for the Preparation of Mono A-Aryl Derivatives of Diethyl Malonate and Ethyl Cyanoacetate using Ethyl-1-Imidazole Carbamate(EImC)

Manoranjan Behera, R Venkat Ragavan, M Sambaiah, Balaiah Erugu, J Rama Krishna Reddy, K Mukkanti, Satyanarayana Yennam
Tetrahedron Letters (December 2011) doi:10.1016/j.tetlet.2011.12.067

Chemistry

Azaindolines: Derisking the Indoline Structural Alert

Eugene L Piatnitski Chekler, Taukeer A Khan, Rajanikanth Mamidala, James T Anderson, Raghuram S Tangirala, Patrick R Verhoest, Adam M Gilbert
Article in Press, doi:10.1016/j.tetlet.2011.11.070

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Chemistry

2010

Chemistry

The First Total Synthesis of Potent Human Chymase Inhibitor SPF32629B via Regioselective Bromination and O-Acylation Strategy

Srinivasa Rao Vegi, Shanthaveerappa K Boovanahalli, Balaram Patro, K Mukkanti
Tetrahedron Letters, 2010, 51, 2768-2770

Chemistry

2009

Biology

LC/MS/MS Method for the Simultaneous Estimation of Losartan Potassium and Irbesartan in Rat Plasma

SVSGB Prasad, Savithiri Shivakumar, T Sudhir, Mitali Ravalji, G Devala Rao
International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009

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Biology

Chemistry

Structure-Based Design of 3-Aryl-6-amino-triazolo[4,3-b] pyridazine Inhibitors of Pim-1 Kinase

Ron Grey, Guy W Bemis, Marc D Jacobs, Cameron Stuver-Moody, Rahul Jajoo, Narinder Mohal, Jeremy Green
BMCL(Bioorganic & Medicinal Chemistry Letters), 2009, 19(11), 3019-3022

Chemistry

Analytical Study of Charge Transfer Complexation of Rabeprazole with 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone

Nadeem A Khan, Avinash B Chaudhary, Balaram Patro, A Devika Rani
Science Asia, 2009, 35(4), 365-371

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Chemistry

2008

Chemistry

The First Total Synthesis of Novel Human Chymase Inhibitor

Srinivasa RaoVegi, Shanthaveerappa K.Boovanahallia, Arun PrakashSharma, K.Mukkanti
Tetrahedron Letters, 2008, 49(44), 6297-6299

Chemistry

2007

Chemistry

The Influence of Drug-Like Concepts on Decision-Making in Medicinal Chemistry

Paul D. Leeson, Brian Springthorpe
Nature Reviews Drug Discovery, 2007

Chemistry

Discovery

Development & Manufacturing

Discovery

Development & Manufacturing

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Publications

2019

Galeterone and the Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-resistant Prostate Cancer Preclinical Models in vitro and in vivo

Oxidative Degradation Profile Studies of Tavaborole by a Validated Stability Indicating RP-UPLC method: Isolation and Characterization of Novel Degradant using 2D-NMR and HRMS

Mass Spectrometry as a Workhorse for Preclinical Drug Discovery: Special Emphasis on Drug Metabolism and Pharmacokinetics

Investigation of the Inhibition of Eight Major Human Cytochrome P450 Isozymes by a Probe Substrate Cocktail In Vitro with Emphasis on CYP2E1

Oral Pharmacokinetics of Sildenafil in the Presence of CYP3A4-Inducer and -Inhibitor using Cannulated and Non-Cannulated Male Swiss Albino Mice

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation In Drug Discovery and Development

2018

Design, Synthesis and Anticancer Evaluation of Spiro[Cyclohexane-1,1’-Indene]-2,5-Diene Analogues

An Efficient Method for the Preparation of N -Formamides using Propylphosphonic Anhydride (T3P)

An Efficient Microwave-Assisted Propylphosphonic Anhydride (T3P®)-Mediated One-Pot Chromone Synthesis via Enaminones

An Efficient One-Pot Green Approach for the Synthesis of A-aminonitriles with Alsba-15 as Nano Tubular Catalytic Reactor

The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group

Highly Efficient Metal-Free One-Pot Synthesis of α- aminophosphonates through Reduction followed by Kabachnik–Fields Reaction Using Three-Component System

First Total Synthesis of Medicinally Important 3,4,7-Trimethoxy-9, 10-Dihydrophenanthrene-1,5-Diol

Preclinical Pharmacokinetics, Antitumor Activity and Single Ascending Dose Tolerability of GBO-006 Nanosuspension, A Selective Polo-Like Kinase 2 (PLK2) Inhibitor

2017

"One-Pot" Selective Synthesis of 3,4-Disubstituted Pyrroles and Benzo[F]Indole-4,9-Diones from 1,3-Indanedione, Aromatic Aldehydes and Tosmic

Synthesis of Novel Fused Chromone–Pyrimidine Hybrids and 2,4,5-Trisubstituted Pyrimidine Derivatives via ANRORC Rearrangement

A Novel Synthesis of Chromone Based Unnatural α-Amino Acid Derivatives

One-Pot Synthesis of 7-chloro-2-arylthieno[3,2-b]pyridin-3-ols and their Derivatization to the Corresponding Arylamino, Arylthio, and Aryloxy

Pd-PEPPSI-Ipentcl: A New Highly Efficient Ligand-Free and Recyclable Catalyst System for the Synthesis Of 2-Substituted Indoles via Domino Copper-Free Sonogashira Coupling/Cyclization

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

Synthesis of Spiroindene-1,3-Dione Isothiazolines via a Cascade Michael/1,3-Dipolar Cycloaddition Reaction of 1,3,4-Oxathiazol-2-one and 2-Arylidene-1,3-Indandiones

Cytochrome P450 Enzymes, Drug Transporters and their Role in Pharmacokinetic Drug-Drug Interactions of Xenobiotics: A Comprehensive Review

Characterization of 1-Aminobenzotriazole and Ketoconazole as Novel Inhibitors of Monoamine Oxidase (MAO): An In Vitro Investigation

2016

Drug Metabolism – Metabolite Identification Using Advance LC-MS/MS System

Design, Synthesis and Biological Evaluation of Diaziridinyl Quinone Isoxazole Hybrids

Design and Synthesis of Diaziridinyl Quinone Thiadiazole Hybrids via Nitrile Sulfide Cycloaddition Reaction as a Key Step

An Efficient Method for the Preparation of N-Formyl-Imide via Amidine using Propylphosphonic Anhydride (T3P®)

I2–DMSO Promoted Metal Free Oxidative Cyclization for the Synthesis of Substituted Indoles and Pyrroles

A New Metabolite of Paricalcitol: Stereoselective Synthesis of (22Z)-Isomer of 1a, 25-Dihydroxy-19-Norvitamin D2

An Efficient Synthesis of 8-Substituted Odoratine Derivatives by the Suzuki Coupling Reaction

Preclinical Formulation for the Pharmacokinetics and Efficacy of GBO-006, a Selective Polo Like Kinase 2 (PLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer

Design, Synthesis, and Evaluation of (2S, 4R)-Ketoconazole Sulfonamide Analogs as Potential Treatments for Metabolic Syndrome

Synthesis of 6-Oxopyrimidin-1(6H)-Yl Benzamide Derivatives and Evaluation of their Antibacterial and Cytotoxic Activity

Design, Synthesis and Biological Evaluation of Diaziridinyl Quinone Isoxazole Hybrids

2015

Synthesis of New Kojic Acid Based Unnatural α-Amino Acid Derivatives.

Pd Catalyzed C–N Bond Forming Reactions of 6-Bromo-2-Cyclopropyl-3-(Pyridyl-3-ylmethyl)-4-quinazolin-(3H)-one at Room Temperature

Facile and Short Synthesis of (+) 1-Hydroxy Indolizidine and (+) Coniceine from Picolinic Acid Ethyl Ester via Cross Claisen Condensation

Synthesis, In Vitro Anticancer And Antimycobacterial Evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino Derivatives

Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N–OH Deoxygenation, and Pd-Catalyzed C–C and C–N Bond Formation

Design, Synthesis, And Biological Evaluation Of Quinazoline Derivatives As α-glucosidase Inhibitors

Breaking the Sensitivity Limitations of Cytochrome P450 Oxidation Product: Dansyl Chloride Derivatization Of 4-OH Mephenytoin, a CYP2C19 Metabolite and its Application to In Vitro CYP Inhibition Assay

Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Estimation of Solutol HS15 and its Applications

Development and Application of PI3K Assays for Novel Drug Discovery

2014

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

Design, Synthesis and Biological Evaluation of Novel Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors

Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

First Total synthesis of (-)-Auranomide C and its Derivatives

Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines

A Convenient and Efficient Synthesis of 2-(Het)arylthieno[3,2-b]pyridine-7(4H)-ones and 2,3-Di(het)arylthieno[3,2-b]pyridine-7(4H)-ones

Pyrrolidine and Piperidine Based Chiral Spiro and Fused Scaffolds via Build/Couple/Pair Approach

Effect of Milnacipran and Atorvastatin Alone and in Combination in Rodent Model of Inflammatory Pain

Optimization of Bupivacaine Induced Subarachnoid Block by Clonidine: Effect of Different Doses of Oral Clonidine

A Randomized Double-Blinded Dose Response Study of the Fentanyl with Hyperbaric Ropivacaine in Caesarean Section

Atorvastatin Potentiates the Anti-Nociceptive Effect of Milnacipran in Carrageenan-Induced Inflammatory Pain Model in Rats

Development of Phosphocellulose Paper-Based Screening of Inhibitors of Lipid Kinases: Case Study with PI3K𝝱

ATP Competition of PI3K Inhibitors using Phosphocellulose Paper Approach

Liquid Chromatography/Tandem Mass Spectrometry Method for Estimation of Cholic Acid in Rat Plasma, Urine and its Application

2013

Identification and Reduction of Matrix Effects caused by Cremophor EL In Bioanalysis using Liquid Chromatography/Tandem Mass Spectrometry

Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Estimation of Polyethyleneglycol 400 and its Applications

Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis

Facile Total Synthesis Of Gymnoconjugatin A and B

A Reagent Based DOS Strategy via Evans Chiral Auxiliary: Highly Stereoselective Michael Reaction Towards Optically Active Quinolizidinones, Piperidinones And Pyrrolidinones

Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation

A Novel One-Pot Synthesis of 7-methoxy-2-arylthieno – [3,2-b] pyridine-3-ols in Domino Fashion

Concise Total Synthesis of (-)-Erinapyrone B from D-(+)-Malic Acid

Development of α-Glucosidase Inhibitors by Room Temperature C–C Cross Couplings of Quinazolinones

Ethyl-1-Imidazole Carbamate (EImC) as a Carbonylating Agent: Efficient Synthesis of Oxazolidin-2-ones from Amino Alcohols