Rodent pharmacokinetic (in life) studies are conducted in the Aragen vivarium on different strains of mice and rats, in accordance with the following certifications, compliances and quality systems:
Ninety SOPs have been established for the regular functioning of the vivarium and for the various studies being conducted.
In-house, experienced scientists conduct cannulations, ensuring minimal stress to the animals, with cost-effectiveness. Sampling can be done through portal/ tail/ saphenous/ submandibular veins. Wherever possible, we employ the principle of 3Rs. Serial sampling is preferred, to reduce the number of animals and generate quality, robust data.
Large Animals: Canine PK studies are conducted with an external collaborator having a colony of more than 400 animals at a time.
| Study Type | TAT (Days) | Compound Requirement (mg) |
| Rat PK | 5 | 25 |
| Mouse PK: serial sampling | 5 | 10 |
| Mouse PK: parallel sampling | 5 | 20 |
| Rat Blood Brain Barrier | 5 | 15 |
| Mouse Blood Brain Barrier | 5 | 15 |
| Cassette dosing | 5 | 25 in rats |
Novel assays for large and small molecule therapeutics, as well as nucleic acid and stem cell therapeutics.
Different animal protocols, optimized planning, and experimental design to accelerate research programs.
We offer a combination of in vitro and in vivo toxicology assays coupled with GLP bioanalysis to help de-risk drug candidates and enable critical and timely go/no-go pipeline decisions.
