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RNA and Protein Degrader/Modulator Modalities of Small Molecules

In the evolving landscape of drug discovery, RNA and protein degrader/modulator modalities have emerged as revolutionary approaches in small-molecule therapeutics. These cutting-edge strategies offer a pathway to tackle previously “undruggable” targets and expand therapeutic horizons across multiple disease areas.

At Aragen Life Sciences, we empower innovation in Integrated Drug Discovery (IDD) by advancing cutting-edge RNA and protein degrader/modulator platforms. Our expertise transforms challenging drug targets into therapeutic realities, enabling breakthroughs across  oncology, CNS disorders, inflammation, metabolic diseases, and more.

RNA-Targeting Small Molecules

Small molecules targeting RNA are reshaping the therapeutic landscape by modulating gene expression at its source. These molecules can:

  • Inhibit RNA-protein interactions, disrupting pathways critical for disease progression.
  • Modulate RNA splicing to restore proper protein function or reduce the production of pathogenic variants.
  • Induce RNA degradation through innovative mechanisms like RIBOTACs (ribonuclease-targeting chimeras), selectively eliminating disease-driving RNA transcripts.

Applications span oncology, rare genetic disorders, metabolic diseases, and infectious diseases, offering precision intervention at the molecular level.

Comprehensive Support for Next-Generation Modalities

As a Contract Research Organization (CRO), we offer end-to-end support in RNA and protein degrader/modulator development, including:

  • High-throughput screening to identify lead compounds.
  • Advanced biophysical and cellular assays for mechanistic validation.
  • Structure-based design leveraging cutting-edge technologies.
  • In vivo models to evaluate efficacy and safety profiles.

Partner with us to pioneer transformative therapies in RNA and protein modulation. Let’s redefine the boundaries of small-molecule drug discovery together.

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