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Solutions Small Molecules Discovery Aragen Integrated Drug Discovery (AIDD) Modalities Protein Degrader

Protein Degrader

Protein Degraders and Modulators

Protein degraders, such as PROTACs (Proteolysis Targeting Chimeras) and molecular glues, have transformed how we approach challenging targets by harnessing the cell’s natural degradation machinery. These approaches:

  • Enable targeted protein degradation by recruiting E3 ligases to unwanted proteins, facilitating their elimination.
  • Provide an alternative to traditional inhibition, allowing dynamic modulation of protein levels rather than permanent binding.
  • Target elusive proteins, such as transcription factors or scaffolding proteins, previously considered “undruggable.”

Our capabilities encompass rational design, synthesis, and screening of small molecules that exploit these mechanisms, ensuring robust discovery and development pipelines.

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