In-vivo Pharmacology: Animal Models
Oncology
Inflammation/Pain
Metabolic Disorders
Fibrosis
- Validated disease models
- Customize existing models to meet specific client needs or develop novel, fit-for-purpose models
Oncology
- Xenograft Models- breast, ovarian, colon, melanoma, multiple myeloma, lung etc.
- Syngeneic Models: melanoma, breast, colon etc.
- PK & MTD studies in tumor bearing mice
Fibrosis Models
- Bleomycin induced Idiopathic Pulmonary Fibrosis (IPF) in mouse & rats
- Carbon Tetrachloride (CCL4) induced liver fibrosis
- Non – Alcoholic Steatohepatitis (NASH)
- Unilateral ureteral obstruction (UUO)
- 5/6 Nephrectomy in rats
Inflammation Models
- Psoriasis (Imiquimod, IL23-induced)
- Delayed type hypersensitivity (oxazolone model)
- MOG-induced Experimental Autoimmune Encephalomyelitis (EAE)
- Dextran sulphate sodium (DSS) induced colitis
- Collagen-Induced Arthritis in in DBA/1J Mice Inflammatory cytokines from plasma and tissues
Pain Models
- Neuropathic (CCI, Chung, STZ and paclitaxel)
- Brennan model
- Inflammatory (CFA, Carrageenan, Formalin & MIA induced mechanical allodynia or thermal hyperalgesia)
Cardiovascular & Metabolic Diseases
- Diet induced obesity (food intake, body weight and clinical chemistry)
- Acute (corn oil or intralipid induced lipid intolerance
- Glucose tolerance test (OGTT, ipGTT, ivGTT)
- Chronic Kidney disease: UUO & 5/6 Nephrectomy
- Monocrotaline-induced Pulmonary Arterial Hypertension (PAH)
- Bleeding Model in rats
Pk-Pd & Non Glp Toxicity Studies
- Oral, IV, IP, SC administration
- MTD and repeat dose toxicity studies in rodents
