One of the huge challenges in leading a successful hit identification (HI) campaign is to obtain a novel molecule with a confirmed structure and reproducible activity in a relevant bioassay. Additionally, target specificity and chemical tractability can pave the way for a strong Hit-to-Lead and further all the way to IND nomination.
AIDD’s medicinal chemistry teams have the knowledge and experience to support you with novel hit generation that can progress all the way to becoming an IND candidate. We employ a multi-pronged approach in generating hits with concomitant data generation. Merging of all this information set against well-established hit evaluation criteria helps generate true hits that can translate into an ongoing lead series.
At AIDD, a hit identification campaign can take anywhere from 2 to 6 months to complete.
What is the best hit-finding strategy?
AIDD teams employ multiple hit identification techniques in engaging with our partners as they aim to discovery a novel hit series.
IDD teams at Aragen typically work with a set of Hit selection criteria agreed with the partner at program initiation. A typical Hit selection criteria set includes setting the cut-offs on the following parameters :
