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Integrated Drug Discovery

Aragen Integrated Drug Discovery (AIDD) platform brings together the strength of our in-house drug discovery capabilities, data science and structural biology/crystallography with a strong focus on efficiency, accuracy and savings.

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In-house Drug Discovery Capabilities
Concept to Proof-of-Concept

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Savings img

Structural Biology, Crystallography and Library Screening*
With our strategic PROTEROS and Nanoimaging partnership

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Accuracyimg

Computational Biology
& Data Science

imgTarget Identification & validation

  • Clear link of MOA to disease model
  • Target based Due Diligence; using genetic or pharmacological toolsTarget based Due Diligence; using genetic or pharmacological tools

imgHit ID

  • Identify compound (s) that modify function or activity of target
  • Structural Biology, crystallography

imgLead Identification

  • dentify one or more chemical series with acceptable preliminary DMPK, safety and potency profile

imgLead Optimization

  • Optimize compounds for DMPK, safety, physiochemical properties
  • Establish in vivo efficacy in appropriate models
imgDevelopment candidate profiling
  • Demonstrate critical physiochemical, DMPK, safety and preclinical efficacy attributes

imgIND Enabling Studies

  • Complete GLP toxicology and safety pharmacology studies, drug substance process, scale up, clinical formulation, clinical supplies manufacture and release and submission package

What we bring:

  • Work in close collaboration with our drug discovery / development partners
  • To develop research strategies and workflows to advance programs from concept to clinic / commercial
  • To de-risk approaches by seeking timely actionable data
  • To provide highest standards of project management to drive the programs efficiently

We have implemented a proprietary digital platform InCoRe for Design-Make-Test-Analyze’ (DMTA) cycle and compound data management system (CDMS) for effective project management.

CDMS is designed to have an integrated digital process platform from compound registration to assay results and data storage for analysis. IDD’s partners can directly monitor the projects in real time and make compound assay requests directly from partner’s location.

This platform is an integration of digital tools as well as customised automated platforms for data acquisition, data transfer and data analysis. It is the integrated discovery workflow for CADD-Medchem-Biology-DMPK that ensures easy tracking, smooth data transfer and clear visualization across the various project stake holders.

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