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Solutions Small Molecules Discovery Aragen Integrated Drug Discovery (AIDD) Integrated Drug Discovery

Integrated Drug Discovery

Aragen Integrated Drug Discovery (AIDD) platform brings together the strength of our in-house drug discovery capabilities, data science and structural biology/crystallography with a strong focus on efficiency, accuracy and savings.

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In-house Drug Discovery Capabilities
Concept to Proof-of-Concept

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Structural Biology, Crystallography and Library Screening*
With our strategic PROTEROS and Nanoimaging partnership

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Accuracyimg

Computational Biology
& Data Science

imgTarget Identification & validation

  • Clear link of MOA to disease model
  • Target based Due Diligence; using genetic or pharmacological toolsTarget based Due Diligence; using genetic or pharmacological tools
imgHit ID

  • Identify compound (s) that modify function or activity of target
  • Structural Biology, crystallography
imgLead Identification

  • dentify one or more chemical series with acceptable preliminary DMPK, safety and potency profile
imgLead Optimization

  • Optimize compounds for DMPK, safety, physiochemical properties
  • Establish in vivo efficacy in appropriate models
imgDevelopment candidate profiling
  • Demonstrate critical physiochemical, DMPK, safety and preclinical efficacy attributes
imgIND Enabling Studies

  • Complete GLP toxicology and safety pharmacology studies, drug substance process, scale up, clinical formulation, clinical supplies manufacture and release and submission package

Our commitment:

  • Deliver IND-enabling program on time and on budget
  • Collaborate with partners as a “biotech for hire” delivering more than simply integrated capabilities
  • De-risk the approach by seeking timely actionable data by bringing extensive knowledge and experience in drug discovery
  • Offer deep expertise in diverse therapeutic areas such as Oncology, Immunology, IO, neuroscience, metabolic disorders and infectious diseases
  • Ensure transparency through regular communication and focus on data integrity

We have implemented a digital platform for ‘Design-Make-Test-Analyze’ (DMTA) cycle and compound data management system (CDMS) for effective project management.

CDMS is designed to have an integrated digital process platform from compound registration to assay results and data storage for analysis. IDD’s partners can directly monitor the projects in real time and make compound assay requests directly from partner’s location.

This platform is an integration of digital tools as well as customised automated platforms for data acquisition, data transfer and data analysis. It is the integrated discovery workflow for CADD-Medchem-Biology-DMPK that ensures easy tracking, smooth data transfer and clear visualization across the various project stake holders.

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