GET IN TOUCH

Integrated Drug
Discovery

Advancing Drug Discovery Programs from Concept to Clinical Candidate Nomination

At Aragen, we understand the diverse challenges faced by our global life sciences customers in advancing their drug discovery programs. Our biology experts work closely with your team, offering consultative support every step of the way-from study design and execution to data interpretation and recommendations. We act as an extension of your internal R&D team, ensuring your projects progress smoothly through the discovery continuum.

We provide crucial support with biochemical and cell-based assay development and drug screening using latest high-throughput platform technologies. Our cell and protein sciences group offering includes generation of reagent proteins, antibodies and engineered stable cell lines for functional and biophysical studies. Our comprehensive in vitro ADME assays and PK studies assist in optimizing drug-like properties and oral bioavailability, while in vivo pharmacology models provide proof-of- concept in various therapeutic areas. We also offer non-GLP in vitro toxicology assays and non-GLP exploratory toxicology studies in rodents for early safety assessment.

Our customized project management platform allows your scientists to focus on high-priority science while our dedicated teams handle logistics, supply chain management, and ensure program efficiency, timely communication, and rapid turnaround time.

Accelerate Discovery Biology Programs with Digital & AI Technologies

At Aragen, we leverage Digital & AI to enhance the efficiency and effectiveness of your discovery biology efforts. Our tailored solutions automate key tasks in your assay lifecycle, helping to reduce manual intervention and accelerate the entire process. Our services provide:

  • Streamlined Automation: Automate critical assay workflow steps—from cell seeding to compound dispensing—using industry-leading technologies for faster, consistent results without sacrificing quality.
  • Efficient Data Handling: Automatically process and analyze raw assay data, ensuring accuracy and reducing manual data handling time for quicker decision-making and reliable insights.
  • Increased Productivity: Automation boosts productivity by approximately 40%, allowing your team to focus on higher-value tasks like data interpretation and strategic decision- making.
  • Customized Automation Solutions: Develop tailored automation workflows to fit the specific needs of your drug discovery programs, maximizing the value of every experiment.

By integrating Digital & AI, we help you enhance the quality, speed, and consistency of your discovery biology programs. These innovations enable you to achieve better results faster and with greater precision.

Reach out to us today to discover how our Digital & AI-powered solutions can elevate your drug discovery process.

Know more about our digital initiatives

Expertise in Key
Therapeutic Areas

Oncology, Pain, Inflammation, Fibrosis, Cardiovascular and Metabolic Diseases

XLRATE

proprietary project management platform

Strong Scientific

Ecosystem located in India and USA

Target Validation and Hit Generation

Hit identification

Hit to
Lead

Lead
Optimization

IND
enabling

  • HTS Analysis
  • virtual screening
  • IP Analysis
  • Tool Compounds
  • Hit validation
  • Focused library design and synthesis
  • Chemical series categorization/ prioritization
  • Robustness check of in silico models
  • SAR analysis
  • SPR profiling
  • Back-up strategy
  • Rapid scale-up
  • Preformulation
  • Route scouting and development
  • Process safety assessment
  • Kilo scale-up
  • Scalability studies
  • Pathway analysis
  • Primary assay
  • HTS
  • Reagent generation
  • In vitro assays:
    – Primary and functional assays
    – Rodent selectivity
  • ADME assays:- Solubility and permeability
    – Stability
    – CYP inhibition
  • In vitro assays
  • Target selectivity
  • Mechanistic assay
  • ADME assay
  • PP binding
  • Rodent PK
  • In vivo target engagement
  • In vivo efficacy
  • PK/PD
  • In vitro safety
  • Rodent tox
  • Canine PK
  • Canine tox
  • CYP inhibition
  • Reactive metabolites, tissue distribution
  • GLP tox
  • Human dose prediction
XLRATE – Project Management Platform
× img

Contact An Expert Today!