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Synthetic
Chemistry

With institutional knowledge of over 20 years, we have been instrumental in bringing platform technologies to deliver exploratory and complex chemistries, using parallel and conventional techniques. A dedicated kilo laboratory and analytical infrastructure with advanced equipment, facilitate the rapid supply of compounds. Our team of 1,200+ talented scientists provide novel, value engineered and environmentally friendly solutions.

Library Synthesis

Accelerating Drug Discovery with High-Throughput Parallel Chemistry

Parallel medicinal chemistry revolutionizes discovery by enabling simultaneous synthesis of large, diverse compound libraries. This high-throughput approach shortens timelines, enhances chemical diversity, and increases the likelihood of identifying potent, selective candidates faster. 

At Aragen, we empower pharmaceutical, agrochemical, animal health, and biotech innovators through comprehensive parallel medicinal chemistry solutions. Our advanced library synthesis capabilities enable rapid exploration of chemical space, accelerating drug discovery and lead compound identification. We leverage cutting-edge technology and expert scientific know-how to propel your discovery projects with speed and precision.

Comprehensive Library Synthesis Solutions

End-to-End Library Synthesis Solutions

  • Comprehensive service covering design, synthesis, purification, and compound management, tailored for large-scale focused libraries and Direct-to-Biology (D2B) formats
  • Multipoint diversification incorporating 1 to 4 diversity points to maximize chemical space coverage
  • Extensive in-house monomer collection of over 16,000 diverse monomers in SD-file format for rapid custom library design
  • High-throughput productivity with expert chemists delivering 90–100 molecules monthly at >95% purity and 10 mg scale for quick biological testing

Scientific Excellence

  • Optimized chemistry platforms fine-tuning reagents, solvents, temperatures, and reaction setups—including block reactors, carousel, microwave, Radleys, Mayo-4—to maximize efficiency and yield
  • Dedicated purification and compound management teams ensuring high-quality purification, precise weighing, QC plate creation, and streamlined logistics
  • Expertise in complex chemistries, including Pd-catalyzed C–C and C–N coupling, delivering robust and scalable libraries

State-of-the-Art Infrastructure

  • Dedicated laboratories equipped with latest synthesis, purification, and QC instruments for high-throughput production
  • Advanced robotics (Gironex, Opentrons) for precision reagent dispensing ensuring reproducibility and speed
  • Automated sample processing (Tecan platforms) for efficient dilution, stock prep, and plate handling
  • High-throughput purification systems (Biotage, Teledyne ISCO Combiflash, mass-directed auto-purification) for high purity isolation
  • Barcode-enabled sample tracking for full traceability and streamlined management

Why Aragen for Library Synthesis?

  • Robust infrastructure with significant investment in instrumentation and automation supporting all discovery stages for reliability and scalability
  • Integrated D2B workflows enabling rapid biological evaluation and informed decision-making
  • Proven track record with 20+ years supporting global discovery initiatives and chemical store housing over 17,000 monomers spanning diverse chemical clusters
  • End-to-end solutions managing design, synthesis, purification, and evaluation under one roof for maximum efficiency
  • Flexible engagement models tailored to your project requirements and timelines
  • Expert teams and project managers handling multiple programs while ensuring quality and confidentiality
  • Commitment to confidentiality, IP protection, and delivering complex, large-scale, time-sensitive projects on schedule and within budget

Partner with Aragen to accelerate your discovery pipeline. Our high-throughput library synthesis solutions combine advanced chemistry, automation, and expert project management to help you go from concept to candidate—faster, smarter, and more efficiently.

Design

  • De novo libraries
  • Target based
  • Natural product based
  • Fragment based

Wet Chemistry Process

  • Scaffold generation
  • Monomer selection
  • Validation
  • Production
  • Purification

Compound Management

  • Plating
  • QC analysis
  • Duplication
  • Storage
  • Unique and diverse building blocks to facilitate immediate library production
  • Library compounds provided with LCMS and/or 1H NMR data
  • Parallel screening platforms, including catalyst screening, photochemical/redox and robotic microwaves
  • Production platforms to accelerate time-to-delivery, including parallel workstations, tumbler stirrers, nitrogen blow down, solvent evaporators, AP-MS and preparative HPLCs

Catalyst Screening

We screen transition metal mediated transformations using preplated catalyst/customized kits in glove boxes.

  • In-house inventory of catalysts, ligands, bases and solvents to screen diverse reaction conditions
  • Commercial kit screening on demand
  • Catalyst screening capabilities under cryogenic, ambient, high temperature and pressure conditions

Asymmetric Synthesis

We have extensive expertise in asymmetric synthesis and chiral induction methods, enabling highly enantioselective or enantiospecific transformations to deliver compounds for the development of novel biomedical therapeutic agents.

  • Chiral pool synthesis
  • Chiral auxiliaries
  • Organometallics chiral catalysts
  • Biotransformation
  • Chemical resolution and/or chiral prep/SFC

Electrochemistry

Pioneering Sustainable, Scalable, and Cutting-Edge Electrochemistry Solutions

At Aragen, our electrochemistry platform leads innovation by delivering cleaner, safer, and more efficient synthetic routes tailored to drug discovery and agrochemical development. Leveraging advanced electrochemical methods, we unlock novel reactivity, enhance process sustainability, and accelerate timelines—from early discovery to kilogram-scale manufacturing.

Comprehensive Electrode Range for Versatile Transformations

Our expert team employs a broad selection of electrode materials—including platinum (Pt), magnesium (Mg), nickel (Ni), copper (Cu), reticulated vitreous carbon (RVC), and zinc (Zn)—to customize electrochemical conditions for diverse synthetic challenges. This flexibility enables efficient oxidative and reductive transformations across multiple chemical classes.

Efficient Cross-Coupling and Scalable Synthesis

Using state-of-the-art equipment such as ElectraSyn 2.0, we perform cross-coupling reactions at scales from 50 mg to 1 g, consistently achieving yields of 40–60%. This accelerates route optimization and reduces reaction times. Additionally, our VersaStat 3.0 platform supports seamless scale-up to kilogram quantities for reproducible, scalable manufacturing.

Proven Success in Real-World Applications

We excel at adapting literature-reported electrochemical reactions to practical medicinal and agrochemical projects, including challenging transformations beyond traditional methods such as:

  • N–N bond formation
  • Fluorination reactions
  • Preparation of halogenated agrochemicals

These capabilities provide new avenues for molecular innovation and competitive project advantages.

Notable Electrochemical Transformations at Aragen

  • Benzylic C(sp³)–H oxygenation for selective functionalization
  • Kilo-scale oxidation of thioethers to sulfones for advanced intermediates
  • Synthesis of phosphorylated indoles and tryptophan-containing oligopeptides
  • Nickel-catalyzed C(sp³)–C(sp³) cross-coupling enabling complex bond formation
  • Nickel-catalyzed aryl amination for medicinal chemistry
  • Late-stage methylation of complex molecules
  • Scale-up of N-arylpyridazinone synthesis from discovery to process chemistry

Environmentally Responsible Chemistry

Our electrochemical synthesis minimizes the use of toxic reagents, aligning with green chemistry principles. By enabling precise electrochemical control, we reduce environmental impact and enhance process safety.

Why Aragen for Electrochemical Synthesis?

Choosing Aragen means access to a world-class electrochemistry platform combining innovative technology with deep synthetic expertise. Our scalable, green electrochemical methods accelerate discovery and development, reduce hazardous reagent risks, and unlock previously inaccessible synthetic possibilities. Leverage our proven capabilities to streamline your synthetic pathways, enhance molecular complexity, and meet project milestones faster.

Photoredox Chemistry 

Unlocking Novel Synthetic Pathways with Light-Driven Catalysis

At Aragen, we harness photo-redox catalysis to transform organic synthesis and accelerate drug discovery and development. Integrating cutting-edge photo-redox technologies, we design and execute innovative synthetic methodologies that unlock previously inaccessible transformations—bringing complex molecular targets to life efficiently and precisely.

Driving Efficiency Through Advanced Photo-Redox Catalysis

Our expertise spans microscale catalyst screening to large-scale production using state-of-the-art technologies. We utilize catalysts based on ruthenium (Ru), iridium (Ir), nickel (Ni), and palladium (Pd), conducting rapid microscale screenings to optimize conditions for your synthetic needs. For scale-up, dedicated photo-flow reactors enable smooth transitions from milligram to kilogram scales, ensuring robust and reproducible outcomes.

Comprehensive Photochemistry Capabilities at Aragen

  • Multiple instruments with BlueLED light sources covering diverse wavelengths
  • Dedicated photo-flow reactors for continuous flow photochemistry and scale-up
  • Extensive photo-redox catalyst inventory enabling broad reaction scopes
  • High-throughput photoredox reaction screening for rapid optimization
  • Expertise in late-stage C–H functionalization for precise complex molecule modification
  • Facilitation of challenging transformations like C(sp²)–C(sp³) coupling, decarboxylative and deoxygenative C–C bond formation
  • Parallel screening under varied UV light conditions accelerating discovery
  • Parallel library synthesis for rapid compound generation
  • Reaction scalability from milligram to kilogram scale
  • Integrated process development supporting medicinal and process chemistry

Versatility Across Broad Chemical Space

Our photoredox platform efficiently couples diverse substrates such as carboxylic acids, esters, halides, alcohols, amines, and boryls. Key transformations routinely delivered include:

  • Trifluoromethylation to introduce valuable fluorinated groups
  • Double bond isomerization for fine-tuning molecular properties
  • Enantioselective amino acid synthesis for chiral drug candidates
  • Classic and novel Diels–Alder reactions forming complex cyclic structures
  • Various cyclizations yielding diverse heterocyclic scaffolds essential for medicinal chemistry

Why Aragen for Photoredox Catalysis?

Partner with Aragen to benefit from a synergy of expertise and technology in photoredox chemistry. We transform synthetic challenges into scalable, efficient, and innovative solutions—delivering projects faster with greater molecular complexity to fuel your pipeline’s success.

FFS capability

Dedicated Fee-for-Service (FFS) Solutions for Accelerated Drug Discovery

At Aragen, we understand that innovation in drug discovery demands agility, precision, and deep scientific expertise. Our Dedicated Fee-for-Service (FFS) model is designed to provide flexible, scalable, and high-quality solutions tailored to your research needs. By partnering with us, you gain access to a comprehensive suite of capabilities across multiple therapeutic modalities and chemistry platforms.

Our Specialty Services

  • Library Design & Screening: We offer end-to-end support for compound library design, synthesis, and screening. Our advanced platforms enable rapid identification of hits and optimization strategies, ensuring a strong foundation for your discovery programs.
  • Peptide Chemistry: Our peptide chemistry team specializes in custom synthesis, modification, and characterization of complex peptide structures. From linear peptides to cyclic, bi-cyclic, tri-cyclic, lapidated, DOTA-chelated, and stapled peptides, we deliver solutions that meet the highest standards of purity and functionality.
  • Nucleotide Chemistry: With expertise in oligonucleotide design and chemical modification with GALNac phosphonamidite, we support the development of next-generation nucleotide-based therapeutics. Our capabilities include synthesis of siRNA, antisense oligonucleotides, and other nucleic acid constructs.
  • Small Molecule Development: Our small molecule services cover the entire spectrum—from hit-to-lead optimization to candidate selection. We combine medicinal chemistry expertise with state-of-the-art analytical tools to accelerate timelines without compromising quality.
  • Rapid Scale-Up: Transitioning from discovery to development requires speed and reliability. Our rapid scale-up services ensure seamless movement from lab-scale synthesis to pilot-scale production, supported by route scouting and robust process optimization.
  • Lipid Chemistry: As lipid-based delivery systems gain prominence in modern therapeutics, our lipid chemistry capabilities enable the design and synthesis of specialized lipids for drug delivery, including LNPs for RNA-based therapies.
  • PROTAC (Proteolysis-Targeting Chimeras): End-to-End PROTAC Solutions—from concept to degrader candidate

Design & Synthesis

  • Warhead selection (known binders, fragments, covalent/non-covalent options).
  • E3 ligase strategies: Cereblon (CRBN), VHL, MDM2, cIAP; exploration of tissue-specific ligases.
  • Linker engineering: length, flexibility, polarity, metabolic stability; cleavable vs. non-cleavable.
  • Parallel synthesis platforms for degrader libraries with rapid SAR turnaround.

Why Choose Our Dedicated FFS Model?

  • Flexibility: Tailored solutions to fit your project requirements.
  • Speed: Accelerated timelines to keep your programs on track.
  • Expertise: Access to multidisciplinary teams with deep domain knowledge.
  • Quality: Rigorous standards and compliance with global regulatory norms.

Partner with us to transform your ideas into impactful therapies.
Contact us today to learn how our dedicated FFS services can empower your drug development journey.

Rapid Scale-up

Driving Innovation with Rapid Scale-Up FFS Capability at Aragen

In today’s fast-paced drug development landscape, flexibility and speed are critical. Our dedicated Fee-for-Service (FFS) model empowers partners to accelerate discovery and development with specialized expertise across multiple modalities:

At Aragen, we are committed to accelerating your molecule’s journey from concept to commercialization with state-of-the-art infrastructure and expertise in rapid scale-up capabilities. Our integrated approach ensures seamless transition from R&D to manufacturing, backed by advanced technology and robust process safety systems.

R&D Excellence

  • Digital IoT-enabled labs for real-time monitoring and data-driven decision-making.
  • Parallel reactors for high-throughput screening and Design of Experiments (DoE).
  • Double Jacketed Reactors (1 L to 20 L) equipped with data loggers and connected to Polestat 2300 for precise process demonstration.
  • Heidolph Rota-evaporators (1 L to 20 L) for efficient solvent recovery.
  • PAR Hydrogenators and autoclaves (250 mL to 25 L) for specialized hydrogenation processes.
  • Wide temperature range (-78°C to +200°C) for complex chemistries using Huber thermostat.
  • Flash Purification machines (Santai SepaBean™ & Orion purification) connected through UV and ELSD detectors.

Robust Reactor Area

  • Diverse reactor portfolio: All Glass (50 & 100 L), GLR (160 L), SS-316 (250 L), Hastelloy (50 & 250 L).
  • Wide temperature range (-78°C to +180°C) for complex chemistries.
  • Autoclaves/Pressure vessels up to 25 L capacity (100 bar, 200°C) in SS-316 & Hastelloy.
  • Supporting equipment: Vacuum tray drier, hot air oven, centrifuge with Halar coating, Nutsche filter.
  • Complete utilities for nitrogen, argon, breathing air, hot water supply, ensuring uninterrupted operations.

Process Safety at the Core

Safety is non-negotiable. Our advanced tools for process safety assessment include:

  • DSC, TSU, Rc1e, ARC, MIT, enabling thorough thermal and reaction hazard analysis.

Cost effective and quick procurement.

Our SCM team are very much efficient to procure KSMs from local and external supplier to achieve cost effective with quick TAT.

With these capabilities, Aragen empowers clients with speed, scalability, and safety, ensuring successful delivery of projects from grams to multi-kilogram scale.

Let’s collaborate to bring your ideas to life—faster, smarter, and safer.

FAQ

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