Unnatural Amino Acid Synthesis

Custom Unnatural Amino Acids — Expand Chemical Space

PeptAR_x specializes in designing and incorporating unnatural amino acids (UAAs)—including D-amino acids, N-methyl residues, conformationally constrained motifs, and THF amino acids—into SPPS workflows to enhance peptide stability, membrane permeability, and target engagement.

Our team combines advanced synthetic strategies with deep expertise to deliver UAAs tailored to your specifications, from laboratory scale to production scale. We maintain an extensive catalog of [500+] UAA products and have successfully customized [100+] UAAs over one year, enabling innovators to push the boundaries of peptide design.

Capabilities & Highlights

• Design & Route Development: Backbone and sidechain engineering; protection strategy selection (Boc, Fmoc, Cbz, Mtt, DDE, IVDDE).
• Stereocontrol & Functionalization: α/β site selectivity; rigid scaffolds; bioorthogonal handles (for conjugation & labeling).
• α-Me-amino acids: Starting from natural amino acids like alanine, we design α-methyl derivatives and extend this approach to leucine, phenylalanine, and others.
• N-Me-amino acids: Proprietary cyclization process enables efficient methylation in just two steps.
• Integration into Peptides: On-resin and solution incorporation; fragment coupling/ligation for long sequences.
• Quality & Scale: Method development, analytical validation, and purification to deliver discovery grade UAAs ready for SPPS.