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Solutions Small Molecules Discovery Chemistry Peptide Platform New

Peptide
Platform

PeptARx— Comprehensive Peptide Capabilities at ARAGEN

Innovating Complexity. Scaling Precision. Empowering Discovery.

With 10+ years of dedicated peptide chemistry experience, PeptARx is Aragen’s integrated platform that helps innovators move peptide therapeutics from concept to preclinical scale—confidently and efficiently. 90 peptide scientists and 40 analytical experts in Hyderabad support you end-to-end: design, synthesis, modification, purification, and largescale non-GMP production.

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PeptARx Platform

Discovery Synthesis (Custom & Libraries): Linear, cyclic, stapled, bicyclic; challenging sequences; long peptides/protein fragments via NCL/KAHA; PNAs; peptidomimetics; segment doubling and solution phase strategies for scale.

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Advanced Modifications & Cyclization: Late-stage functionalization; hydrocarbon stapling; disulfide/lactam/thioether cyclizations/C-C bond formation; PEGylation (to 40 kDa), phosphorylation, sulfation, glycosylation; C- and N-terminal modifications.

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Peptides Conjugates: PEG, lipids, carbohydrates, steroids, DOTA, fluorophores—engineered for imaging, targeting, and delivery; bioconjugation/peptide-protein conjugation, Peptide-PMO (PPMO), Peptide-Oligonucleotide (POC), Peptide-Drug (PDC).

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Unnatural Amino Acids & Backbone Engineering: N-alkylated amino acids, conformationally constrained amino acids, β- amino acids, glycosylated amino acids, stereoselective synthesis of novel amino acids.

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Scale-Up & Non-GMP Supply: >500 g batches, >98% purity, scalable toward kilogram.

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Why PeptARx?

  • Expertise in Complex Chemistry: Multifunctional, challenging sequences; long peptides via ligation; protein fragments.
  • Comprehensive Technology Stack: Solid phase, liquid phase, hybrid; convergent routes for scale.
  • Unnatural Amino Acids: 500+ catalogued unnatural amino acids (UAAs) and capability of synthesizing novel UAAs.
  • End-to-end Support: Robust analytics, purification, and scaleup from discovery to non-GMP supply.
  • Advanced Modifications: Nonstandard residues, conjugates, late-stage functionalization.
  • Scalable Infrastructure: Flexible transition from R&D to INDenabling with reliable output.
Let’s advance your peptide pipeline with PeptARx

Infrastructure for Synthesis & Scale-Up

  • Automated Platforms: CEM MultiPep 2, CEM Liberty Blue 2.0, Biotage Alstra, SYMPHONY® X24.
  • Scale-Up Reactors: SONATA®/XT, 10 L jacketed reactors (solid & solution phase).
  • Library Synthesis Tooling: 48 station SiliCycle block; orbital shakers, centrifuges, manual setups.
  • Scale Range: Milligram to >500 g (non-GMP), scalable to kilograms; pseudoproline dipeptides & solubility tags for difficult sequences.

Analytical & Purification

  • Techniques: LCMS/HRMS, HPLC, ¹H NMR; water content, residual solvents, heavy metals, counterions; inprocess LCMS/HPLC after coupling steps.
  • Prep HPLC: Flow rates up to 300 mL/min; DAC/SAC hardware (30–100 mm ID), packed inhouse; 10+ column chemistries (Sunfire C18, Aeris Peptide XBC18, XBridge, Jupiter C18, Capcell Pak, BEH, Proteonavi, and more).
  • Purification Range: 1,000–20,000 Da; outputs from mg to g, 24/7 support.

We apply late-stage functionalization techniques in PeptARx such as desulfurization, S-arylation, and double-lactam bridge formation, enabling precise tuning of peptide properties for therapeutic applications. Modifying peptides for augmented bioavailability, stability, and receptor specificity can optimize their therapeutic potential. Whether it’s improving cellular uptake, increasing half-life, or enabling targeted delivery, our modifications help make peptides more effective and versatile in their application.

Peptide Solutions for Every Application

At Aragen, we specialize in synthesizing a diverse portfolio of peptide classes, each engineered for specific therapeutic and diagnostic applications. Our expertise ensures you have access to the exact peptide tools required to investigate novel targets, explore unique mechanisms of action, and optimize delivery strategies for your research and development goals.

Peptide Type Features & Applications
Cyclic Peptides Increased enzymatic stability and receptor affinity, ideal for drug discovery and peptide vaccines
Disulfide-Bridged Peptides Structural stability and mimicking protein loops for targeting intracellular proteins and receptors
Stapled Peptides Enhanced α-helicity, protease resistance, and cell penetration for intracellular targeting
Bi-cyclic Peptides High binding specificity and metabolic stability for use in diagnostics, imaging, and therapeutics
Boronic Acid Peptides Reversible binding to diols for sensing applications, proteasome inhibition, and controlled delivery
Glycopeptides Carbohydrate-modified peptides for immune modulation, receptor selectivity, and diagnostic purposes; synthesized using advanced linkers like 4-(hydroxymethyl)phenol
DOTA-Derivatized Peptides Radiolabeling-ready scaffolds for imaging and targeted therapy
Fluorescent/Tagged Peptides Chromophore and fluorophore additions for visualization, molecular tracking, and real-time imaging; successfully conjugated at >1 g scale with >97% purity
Synthetic Protein Fragments Long peptides (>150 AAs) synthesized via NCL/KAHA for structure-function studies and drug targets

 

PeptARx Infrastructure for Synthesis & Scale-Up

Our state-of-the-art synthesis platforms and scale-up capabilities within PeptARx enable us to support projects from early-stage discovery to large-scale production.

Automated Synthesis Platforms

  • Small to medium scale: CEM-MultiPep 2, CEM Liberty Blue 2.0, Biotage Alstra, SYMPHONY® X-24, PTI Prelude
  • Scale-up reactors: SONATA®/XT, 10L jacketed reactors for solid- and solution-phase synthesis
  • Library synthesis: 48-station SiliCycle block, orbital shakers, centrifuges, manual setups

Scale Range

  • From milligrams to >500 g (non-GMP), scalable to kilograms
  • Crude to final purities >98%; single impurity <0.5% achievable
  • Pseudoproline dipeptides and solubility tags used for difficult sequences

Our scalable systems in PeptARx, from small-scale R&D to larger preclinical supply, minimize the risk of technology transfer and provide flexibility across stages of discovery and development. Whether you’re progressing from the lab to IND-enabling studies or moving toward commercialization, PeptARx helps facilitate each stage with reliable output and consistency.

Analytical & Purification Capabilities

Ensuring the purity and identity of your peptides is paramount, and our advanced analytical techniques and purification infrastructure are designed to meet those needs.

Analytical Techniques

  • Purity and identity verification: LCMS, HRMS, HPLC, ¹H NMR
  • Quality assurance: Water content, residual solvent, heavy metal, and counterion analysis
  • Process control: In-process LCMS/HPLC checks after amino acid coupling steps

Infrastructure & Columns

  • Prep HPLC: Systems with flow rates up to 300 mL/min
  • Column hardware: DAC and SAC, 30–100 mm ID, packed in-house
  • Diverse chemistries: Over 10 column options including Sunfire C18, Aeris Peptide XB-C18, XBridge, Jupiter C18, Capcell Pak, BEH, Proteonavi, and more

Purification Range

  • Peptides from 1,000 Da to 20,000 Da
  • Output: Milligram to gram quantities with 24/7 support

With these resources available in PeptARx, you gain rapid method development, consistent quality control, and the confidence that your peptides meet the highest standards of purity—essential for advancing your projects toward clinical testing.

Resins & Reagents

We utilize a broad array of resins and coupling reagents within PeptARx to ensure optimized peptide synthesis. The right resin and reagent choice significantly impacts yield, purity, and functionalization.

Resins In Routine Use

  • Wang (polystyrene and Chemmatrix), Rink Amide (AM, MBHA), Sieber Amide, Tentagel, 2-Cl CTC, Ramage, Dbz, Sulfamylbutyryl
  • Specialized for C-terminal amides, protected peptides, aldehydes, thioesters, and aggregation-prone sequences

Coupling Reagents

  • DIC, HATU, HBTU, COMU, PyBOP, PyAOP, DEPBT, EEDQ

The strategic selection of resins and reagents tailored for your specific peptide sequences within PeptARx ensures the optimization of synthesis, leading to higher purity, more efficient yields, and reliable outcomes even for complex, challenging peptides.

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