Process Engineering

At Aragen, we empower scientists and engineers to adopt a data-oriented development approach, ensuring flawless scale-up of processes. Our comprehensive services cover a wide range of specialized areas, including crystallization and polymorphism studies, risk assessment, and process development.

Crystallization & Polymorphism Studies:  Our expertise in crystallization and polymorphism studies includes:

• Solubility Analysis: We conduct thorough solubility studies to understand the solubility behavior of compounds under various conditions. This forms the foundation for optimizing crystallization processes.
• Metastable Zone Width (MSZW) Determination: By determining the MSZW, we can identify the optimal conditions for nucleation and crystal growth, minimizing the risk of undesirable polymorph formation.
• Crystallization Parameter Optimization: Our team optimizes crystallization parameters to ensure the formation of high-quality crystals with desired properties.
• Polymorph Screening and Development: We perform extensive polymorph screening to identify and develop stable polymorphic forms, enhancing the physical and chemical properties of the final product.

Risk Assessment: Ensuring process safety is paramount in our development approach. Our risk assessment services include:

• Differential Scanning Calorimetry (DSC): We utilize DSC to study the thermal properties of materials, identifying potential thermal hazards and decomposition temperatures.
• Thermal Safety Unit (TSU) Studies: Our TSU studies evaluate the thermal stability of compounds, providing crucial data for safe process development.
• Calorimetric Studies: We conduct comprehensive calorimetric studies to assess the exothermic and endothermic behavior of reactions, ensuring process safety and stability.

Process Development: Our process development capabilities encompass a wide range of unit operations and optimization studies:

• Unit Operations Simulation: We perform detailed simulation studies for various unit operations such as filtration, drying, and milling. These simulations help in predicting performance and identifying potential issues before scale-up.
• Scale-Up Studies: By conducting “what-if” analyses and scale-up studies in geometrically similar reactors, we ensure seamless transition from lab-scale to commercial-scale production.
• Optimization of Non-Conventional Unit Operations: We specialize in optimizing non-conventional unit operations such as chromatography and ultrafiltration, tailoring processes to achieve maximum efficiency and product quality.

Process Engineering Laboratory: State of Art Infrastructure

• Online pH monitoring and control
• Online turbidity monitoring
• Online reaction monitoring (React-IR) React-IR 45m: 
• In situ mid-infrared based system that monitors reactive chemistry to under reaction conditions
• Online particle size measurement-with Raman probe & Particle Vision Microscope (PVM)
• Jacketed reactor equipped with Huber and Julabo circulation unit – Temperature: -50 – 180 °C
• Poly block – Parallel synthesis unit – Min & Max volume: 10 ml – 500 ml
• Rotocone Vacuum Dryer (RCVD) – Capacity: 100 g – 1 kg
• Centrifuge – Capacity: 50 g – 500 g, Volume: 400 cc – 750 cc
• Agitated Nutsche Filter Dryer (ANFD) – Capacity: 100 g – 1 kg
• Nauta Dryer – Capacity: 100 g – 1 kg