Drug metabolism and pharmacokinetics (DMPK) team at Aragen-IDD is well-positioned to provide accurate data and insightful analysis of a drug’s absorption, distribution, metabolism, and excretion (ADME) properties. This is to help partners shortlist compounds with a high chance of success in later stages of drug development. By conducting the right PK & ADME studies, we help reduce failure of preclinical candidates at the clinic for human evaluation, identify compounds with optimal safety profiles and minimize drug-drug interactions (DDI) in later stages of the discovery & development process.
Capabilities
We offer a comprehensive suite of DMPK studies, including in-vitro ADME and in-vivo pharmacokinetics (PK) studies, that cover both the drug discovery and early drug development phases. Our capabilities include developing class-leading customized assays and implementing a range of protocols as specified by partners.
Fig: ADME/PK Capabilities at Aragen
Through formulation development studies on the characteristics and biological activity of a compound, we help partners make decisions on a drug’s delivery system using attributes such as solubility, self-emulsification, and dosage form. Our well-defined bioanalytical qualification process to quantitatively measure active drugs is shown below.
Our scientists are experts in driving cost-effective, reproducible and high-quality data for drug discovery and development programs. The team handles compound dispatch to data upload in 10 calendar days with more than 95% adherence to turnaround time.
Our state-of-the-art infrastructure includes automated solutions, such as ultra-performance liquid chromatography (UPLC) and time-of-flight (Tof) mass spectrometry, which enable rapid processing of bioanalytical data for fast-tracking of drug discovery projects.
Our in-vitro ADME and in-vivo pharmacokinetics (PK) studies can be accessed as a stand-alone project (i.e., fee-based or service-based model) or as part of a larger integrated drug discovery (IDD) program.
Fig: In-vitro ADME solutions
Fig: In-vivo PK solutions
Development of bioanalytical methods to support bioavailability and pharmacokinetics studies.
