Aragen has three state-of-the-art vivarium facilities – one each in Bangalore and Hyderabad in India and in California in the United States. These facilities have individually ventilated caging, automated temperature, humidity and access control systems with round-the-clock monitoring by dedicated veterinarians and trained staff. Rodents procured from globally reputed vendors such as Taconic Biosciences, Charles River Laboratories and The Jackson Laboratory support in vivo efficacy, pharmacokinetics and exploratory toxicology for clients.
Aragen is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) and all animal experiments are conducted in accordance with protocols approved by the Institutional Animal Ethics Committee (IAEC). Our in vivo pharmacology consists of non-GLP studies performed exclusively in rodent models. We have a long tradition in the humane and proper use of laboratory research animals for biological and biomedical research. The Institutional Animal Care and Use Committee (IACUC) serves as an independent oversight committee responsible for monitoring all associated animal care and use at Aragen. Accrediting agencies such as the USFDA and the Public Health Service/National Institutes of Health/Office of Lab Animal Welfare (OLAW) monitor the IACUC’s operations. Aragen also holds a Controlled Substance License from the US Department of Justice/Drug Enforcement Administration (DEA).
Certification & Compliance
AAALAC and OLAW-accredited rodent vivarium facilities
Regulatory
OHSAS (Occupational Health and Safety Assessment Series) compliant
Institutional Animal Ethics Committee (IAEC) constituting external members and CPCSEA nominee
IAEC committee reviewed and approved protocols of study experimentation
Institutional Bio Safety Committee (IBSC) registered under Department of Biotechnology
Bio-waste Disposal Management registered under State Pollution Board
EMS (Environment Management System as per ISO 14001)
Large animal (canine) PK studies with external collaborator
Quality Systems
Documentation of animal health status at receipt
Quarantining and physical examination of newly arrived animals by a veterinarian
Clinical tests of animals
Parasitological examination
Hematological
Biochemical
Microbiological examination of faeces for pathogenic organisms on blood agar
Feed, water and bedding material analysis
Dedicated veterinarians and pathologists to support efficacy and toxicity studies
Ethical efforts to avoid pain and distress to experimental animals
Anesthesia and euthanasia as per CPCSEA guidelines
