Comprehensive Peptide Solutions

For over a decade, Aragen has delivered specialized peptide discovery and development solutions through our integrated peptide platform—PeptARx. It takes you seamlessly from concept to clinic. PeptARx is powered by a 130+ member peptide team, including 90 chemists and 40 analysts, and strengthened by in-house biology teams. With unmatched speed and reliability, PeptARx accelerates peptide discovery and development, synthesizing nearly 400 peptides, ranging from milligram to multigram scale every month to help you meet timelines without compromise.

Chemistry Expertise

Metal catalyzed or metal free late-stage modification of peptides.
Protein synthesis ( > 150AA) in gram scale
Linear, branched, cyclic and stapled peptides
40-50 AA, mg to gm, Peptide libraries
Solid, liquid, hybrid, TAG-assisted, native
chemical/KAHA ligation
C- & N-terminal, cyclization, backbone modifications, late-stage functionalization, and conjugation reactions
Non-GMP scale-up
Purification and characterization

Biology Expertise

Peptide mapping/ fingerprinting
Plasma protein binding using Rapid Equilibrium Dialysis or Ultrafiltration
Stability in buffer, simulated gastric fluids, liver, kidney, intestinal S9, hepatocytes or plasma
Half-life, metabolite identification and profiling
Pharmacokinetics and Quantitative bioanalysis: rat, mouse, dog, rabbit
Mass/ QTOF spectrometry analysis

Track Record of Success

Library development: linear/cyclic peptides, 2-20 mg, up to 20mer, >90% purity
Successful synthesis of challenging peptide moieties
Hydrophobic peptides with disruptors (dmb, hmb protected amino acids / pseudoprolines, chaotropic agents)
Cyclic peptides (S-S bridging, cyclization, stapling, RCM, thioether)
Process optimization and non-GMP scale-up to multi-gm scale (>500g, 98% pure, single impurity <0.5%)
Modified interleukin protein synthesis (>150 amino acid, >10g scale) using ligation techniques (NCL/KAHA)
Long chain peptides and folding