Peptide Technology Platform

Peptide mapping/ fingerprinting
Plasma protein binding using Rapid Equilibrium Dialysis or Ultrafiltration
Stability in buffer, simulated gastric fluids, liver, kidney, intestinal S9, hepatocytes or plasma
Half-life, metabolite identification and profiling
Pharmacokinetics and Quantitative bioanalysis: rat, mouse, dog, rabbit
Mass/QTof spectrometry analysis

Track Record of Success

Library development: linear/cyclic peptides, 2-10 mg, up to 50 mers, >95% purity
Successful synthesis of challenging peptide moities
- Hydrophobic peptides with disruptors (dmb, hmb protected amino acids / pseudoprolines, chaotropic agents)
- Cyclic peptides (S-S bridging, cyclization, stapling, RCM)
- Process optimization to multi-gm scale
- Long chain peptides and foldings (>100 mers, NCL/KAHA)