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Brochure

Comprehensive GLP-regulated Ecotoxicology Services

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Environmental toxicity studies play a critical role in understanding the potential risks and hazards associated with various compounds. It also facilitates protection and preservation of ecosystems, promote sustainable practices, and safeguard human and environmental health. At Intox, we provide a comprehensive range of environmental toxicology and ecotoxicology studies to determine threshold toxicity concentrations of a range of test compounds. Our teams of qualified and experienced environmental chemists provide integrated approach to ecotoxicity and environmental risk assessments, delivering high quality reliable results to meet the needs of the global industry and environmental regulators. With end-to-end capabilities to support advance ecotoxicology and analytical chemistry techniques using a wide variety of species and a track record of successful regulatory submissions, we can offer customized study protocols to meet the clients’ requirements.

Comprehensive array of ecotoxicology services at Intox:

Aquatic

In order to meet the regulatory requirements for agrochemicals, industrial chemicals, and human and veterinary pharmaceuticals, comprehensive aquatic ecotoxicology data plays a vital role in Environmental Risk/Impact Assessments (ERA and EIA). Intox provides a diverse range of aquatic ecotoxicology tests, encompassing the following:

  • Growth Inhibition Test (Algae: OECD-201)
  • Acute Immobilisation Test (Daphnia magna:
    OECD-202)
  • Fish, Acute (Guppy,carp, Zebrafish: OECD-203)
Terrestrial

Diversity of terrestrial organisms – plants, invertebrates, and vertebrates – living in and on the soil makes hazard assessment of a chemical on a terrestrial environment critical and more complex. Our terrestrial ecotoxicology tests include

  • Avian (Dietary, Acute oral: OECD-205/223)
  • Earthworm (Acute: OECD-207, Reproduction:
    OECD-222
  • Subchronic Toxicity Test (Earthworm:
    OCSPP-850.3100)
  • Honeybee Acute Toxicity (Oral: OECD-213,
    Contact: OECD-214)
  • Nitrogen Transformation Test (Soil Microorganisms: OECD-216)
  • Carbon Transformation Test (Soil Microorganisms: OECD-217)

Salient features of our services:

  • Test system – Identification/Characterization certificate
  • Use of replicates
  • Monitoring of variables (water /soil / environment parameter)
  • Use of reference item
  • Use of organic solvents as vehicle
  • Limit of solubility, Analytics
  • Geometric series of dose selection
  • Optimization of study results and validity criteria
  • Endpoint – Mortality / Inhibition / immobilization
  • Lithal dose (LD50), Lithal concentration (LC50), Effective concentration (EC50), Noobserved effective concentration (NOEC), Low observed effective concentration (LOEC)

Proven expertise and valuable experience

  • > 100 Acute toxicity studies- Fish
  • > 96 Acute Toxicity studies- Honeybees (Contact)
  • > 85 Avian Acute Oral Toxicity-Japanese quail
  • > 85 Acute toxicity studies- Honeybees (Oral)
  • > 80 Acute Toxicity Test – Earthworm
  • > 50 Algal Growth Inhibition Test
  • > 55 Acute Immobilization Test – Daphnia magna
  • > 35 Avian Acute Oral Toxicity studies – Pigeon
  • > 25 Avian Acute Oral Toxicity studies – Chicken
  • > 10 Avian Dietary Toxicity Studies
  • > 5 Biological Method Validations on Mosquito larvae – Aedes aegypti

Animal husbandry at Intox:

Aquatic
  • Algae
    Test species: Unicellular green algae,
    Pseudokirchneriella subcapitata
  • Daphnia
    Test species: Daphnia magna
  • Fish
    Test species: Brachydanio rerio
    (Zebra fish), Poecilia reticulata
    (Guppy), Cyprinus carpio
    (Common carp)
Terrestrial
  • Honeybee
    Test species: Apis mellifera
  • Earth worm
    Species: Earthworm – Eisenia foetid
Terrestrial (Avian)
  • Chicken
    Species: Gallus domesticus
  • Pigeon
    Species: Columba livia
  • Quail
    Species: Coturnix japonica